Brain cells are constantly swallowing material from the fluid that surrounds them—signaling molecules, nutrients, even pieces of their own surfaces—in a process known as endocytosis that is essential ...

While physicians and scientists have long known that Alzheimer's disease involves the buildup of toxic protein fragments in the brain, they have struggled to understand how these harmful fragments are ...

Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. Aβ accumulation in the brain is proposed ...

Researchers at Brown University and the Marine Biological Laboratory at Woods Hole, Mass., have found a physical connection between the herpes simplex virus and amyloid precursor protein, a protein ...

A new study strengthens the idea that reelin, an extracellular matrix protein essential for brain development, works, at least in part, by binding amyloid precursor protein (APP). In the June 10 ...

β-Secretase (BACE, Asp-2) is a transmembrane aspartic proteinase responsible for cleaving the amyloid precursor protein (APP) to generate the soluble ectodomain ...

A new study published in the journal JAMA Neurology in April 2020 seems to indicate that higher brain amyloid levels represent early Alzheimer's disease (AD). Amyloid-beta is a significant biomarker ...

(A, B) ALP staining and activity detection were performed after treating cells with APPswe or BMP2 for 5 days or 7 days. (C, D) ARS staining and semiquantitative analysis were used to detect calcium ...