To understand better and more deeply appreciate the development of knowledge in this field, it is desirable to begin with the simpler aspects of the action of these glycosides and then to proceed to ...

The unfolded protein response (UPR) is a pivotal mechanism to mitigate protein homeostasis through transcriptional or translational control. On the other hand, since dysregulation of UPR has been ...

Cardiac glycosides reduce a precursor of LDL cholesterol in a drug screen of statin-resistant hypercholesterolemia, new research concludes. A large meta-analysis of medical records revealed that ...

Several drugs now being used to treat heart failure and atrial arrhythmia also show promise as DNA disruptors in cancer cells and could be readily repurposed as anticancer agents, according to a new ...

THE cardiac glycosides have been shown to be specific inhibitors of active cation transport in a wide variety of tissues 1–4. The specificity of this inhibition was first demonstrated by Schatzmann, ...

MADRID -- Digitoxin added to guideline-directed medical therapy improved outcomes among patients with heart failure and reduced ejection fraction (HFrEF), the DIGIT-HF trial showed. The cardiac ...

Considering taking supplements to treat Cardiac glycoside induced ventricular arrhythmias? Below is a list of common natural remedies used to treat or reduce the symptoms of Cardiac glycoside induced ...

In the present study, Dr. Hidetoshi Hayashi (Professor, Nagoya City University) and collaborators screened small-molecule compounds that suppress UPR, using Myanmar wild plant extracts library. The ...