The corticospinal tract (CST) is extensively used as a model system for assessing potential therapies to enhance neuronal regeneration and functional recovery following spinal cord injury (SCI).

Background Recent evidence has suggested that corticospinal excitability alterations are present in the surrounding ankle musculature in individuals with chronic ankle instability (CAI). However, ...

The hereditary spastic paraplegias (HSPs) are genetic conditions in which spasticity of the legs is caused by degeneration or abnormal development of the distal ends of the corticospinal tract's ...

Background Previous studies have suggested that hamstring strain injury leads to activation and strength deficits in hamstring muscles. However, the effects of previous hamstring strain injury on the ...

The brain orchestrates movement via two major neural highways descending to the spinal cord: the corticospinal tract (CST) and reticulospinal tract (RST). The CST is thought to be the dominant pathway ...

A preclinical study with mice has shown that Gabapentin, a drug that is commonly used in nerve pain could be useful for patients with spinal cord injury. Use of the drug showed improvement in upper ...