Researchers discovered a kinase-driven phosphorylation switch that activates DNA packaging machinery, aligning nucleosomes at ...

DNA replication is a fundamental process essential for bacterial growth and survival. Initiation begins at the chromosomal origin (oriC), where the conserved initiator protein DnaA assembles into an ...

The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must ...

DNA replication is a complex process with many moving parts. In baker's yeast, the molecular complex Ctf18-RFC keeps parts of the replication machinery from falling off the DNA strand. Human cells use ...

When bacteria cells replicate, they do so a little differently than human cells do. They don't undergo mitosis, a splitting that involves construction of spindles to carefully separate the DNA after ...

If parent cells and their daughter cells are to share a stable identity, parent cells must divide—and replicate their DNA—while ensuring that their histones are distributed properly to their daughter ...

Researchers have identified a physical process called “mitochondrial pearling” that explains how cells keep their ...

Scientists reveal a hidden second layer of human DNA, showing how genome folding controls genes and influences disease development.

New work shows that physical folding of the genome to control genes located far away may have been a critical turning point for life on Earth. For evolutionary biologists, what most distinguishes the ...

Researchers at the University of Bristol have caught DNA-copying enzymes generating long stretches of genetic code without ...

Before a cell can divide, it has to precisely duplicate its entire genetic information. However, the DNA in the cell exists ...