The increasing interest in Bayesian group sequential design is due to its potential to reinforce efficiency in clinical trials, shorten drug development time, and enhance the accuracy of statistical ...

Randomized clinical trials serve as the standard for clinical research and have contributed immensely to advances in patient care. Nevertheless, several shortcomings of randomized clinical trials have ...

Decline in the use of erythropoiesis-stimulating agents: Long-term effects of regulation, reimbursement, and unfavorable data. Effect of a topoisomerase-1 inhibitor (topotecan) on the efficacy of ...

Noninvasive Application of Alternating Electric Fields in Glioblastoma: A Fourth Cancer Treatment Modality Adaptive designs are aimed at introducing flexibility in clinical research by allowing ...

Response to treatments is highly heterogeneous in cancer. Increased availability of biomarkers and targeted treatments has led to the need for trial designs that efficiently test new treatments in ...

A recent study has shown that a more flexible approach to study design can significantly improve the efficiency of preclinical research. The translation of preclinical research findings into effective ...