The most widely used technique for finding the largest or smallest values of a math function turns out to be a fundamentally difficult computational problem. Many aspects of modern applied research ...

Wnt proteins function as morphogens that can form long-range concentration gradients to pattern developing tissues. Here, we show that the retromer, a multiprotein complex involved in intracellular ...

As a tangent is a straight line it is described by an equation in the form \(y - b = m(x - a)\). You need both a point and the gradient to find its equation. You are usually given the point - it's ...

See "Nonlinear Optimization and Related Subroutines" for a listing of all NLP subroutines. See Chapter 11, "Nonlinear Optimization Examples," for a description of the inputs to and outputs of all NLP ...