Deep in the lungs, resident memory B cells stand guard against influenza reinfection—but whether they remain there may depend ...
Researchers have identified an unexpected mechanism that links age-related stress to the decline of blood-forming stem cells. Instead of triggering cell death, a known signaling pathway subtly ...
A new review links three forces shaping osteoarthritis: mechanical stress, integrin signaling, and integrin endocytosis. The authors argue that integrin trafficking can reprogram where and how long ...
A study shows that high levels of negatively charged lipids can lock growth receptors into an overactive state, driving ...
T cell activation—the process by which these key immune defenders recognize threats and mobilize against them—depends on exquisitely timed molecular signals. Now researchers have captured one of the ...
BACKGROUND: Despite antiplatelet therapy, some patients remain at high ischemic risk because of drug nonresponsiveness or high residual platelet reactivity). We aimed to target an orphan platelet GPCR ...
A study reveals how MLKL drives stem cell aging by damaging mitochondria without causing cell death, reducing regenerative ...
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