Chemical structures called cyclopropanes can increase the potency of many drugs, but traditional methods to create this structure require highly reactive -- potentially explosive -- ingredients. Now, ...

Generative artificial intelligence is moving from the margins of pharma into the center of how new medicines are imagined, ...

After training as a mathematician and physicist, Felix Wong, PhD, developed a keen interest in biology. He found the perfect fit in the lab of James J. Collins, PhD, at MIT, where he started using ...

An international team involving the Institute of Chemical Research, a joint center of the University of Seville and the Spanish National Research Council, has developed a new technique that will ...

A version of this story appeared in Volume 100, Issue 23 And yet a look at drugs that have made it into the clinic reveals that the pharmaceutical industry has explored only a fraction of that ...

The FDA and EMA require CNS penetrant drug candidates to be assessed for abuse potential. As part of this assessment, the chemical similarity to known drugs of abuse is analyzed. Scitegrity Limited ...

WASHINGTON, Aug. 20, 2025 — How do you identify something no one has a test for? Designer drugs replicate the effects of known, illicit drugs but evade law enforcement. The chemical structure ...

FDA recently awarded new chemical entity (NCE) exclusivity to Austedo™ (deutetrabenazine). The Austedo approval is notable for two reasons: One, it is the first deuterated drug (i.e., a drug ...