Saol Therapeutics received a complete response letter for its pyruvate dehydrogenase complex deficiency treatment a week ...

The Food and Drug Administration (FDA) has accepted for Priority Review the New Drug Application for SL1009 (sodium dichloroacetate oral solution) for the treatment of pyruvate dehydrogenase complex ...

Neutron scattering has revealed how massive enzyme complexes inside cells might determine whether sugar is burnt for energy or stored as fat. The findings promise to improve understanding of diabetes ...

Time-of-day defines NAD + efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice NADPH drives the synthesis of deoxyribonucleotides, proline and fatty acids. We ...

Tumours derive most of their energy by metabolizing sugar in a process called glycolysis, which healthy cells typically use only when oxygen levels are low. A team has shown that cancer cells silence ...

Lung cancer, notorious for its high mortality rates, is a leading cause of cancer-related deaths globally, with metastasis being the primary contributor to poor patient outcomes. A critical factor in ...

A new method has enabled the natural structure of particularly large and complex enzymes to be revealed. Scientists at Martin Luther University Halle-Wittenberg (MLU) and TU Berlin have published ...

Indications: Pyruvate dehydrogenase complex deficiency, typically associated with post-prandial lactic acidemia with a normal lactate/pyruvate ratio, can be assayed in freshly isolated blood ...

Leucoplast pyruvate kinase ($\text{PK}_{\text{p}}$; EC 2.7.1.40) from endosperm of developing castor oil seeds (Ricinus communis L. cv Baker 296) appears to be highly susceptible to limited ...

A new method has enabled the natural structure of particularly large and complex enzymes to be revealed. Scientists at Martin Luther University Halle-Wittenberg (MLU) and TU Berlin have published ...

Acute myeloid leukemia (AML) remains harder to treat therapeutically due to the high existing genetic heterogeneity not only between patients but also between the population of subclones of cancer ...

A new method has enabled the natural structure of particularly large and complex enzymes to be revealed. Scientists have investigated a multi-enzyme complex that plays an essential role in metabolism ...