The process of GLUT4 trafficking is central to the metabolic regulation of blood glucose levels. In both muscle and adipose cells, the insulin hormone triggers the mobilisation of intracellular ...

A group of researchers has clarified the role of a N-glycan chain on glucose transporter type 4 (GLUT4) by developing a method for visualizing intracellular trafficking of proteins. A group of ...

Type 2 diabetes (T2D) has become one of the leading chronic diseases worldwide in terms of both incidence and mortality. According to the International Diabetes Federation (IDF), approximately 537 ...

On phosphorylation of Cbl, the c-Cbl-associated protein (CAP)/Cbl complex dissociates from the insulin receptor and translocates to a lipid raft membrane fraction to form a ternary complex with ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, No. 23 (Nov. 10, 1998), pp. 13567-13572 (6 pages) SecA, the translocation ATPase in Escherichia coli, ...

Chromosomal translocations occur in leukemias, lymphomas, sarcomas and some epithelial tumors and some generate unique fusion proteins. These translocation products may provide tumor-specific targets ...

This article describes the various methods available to measure glucose uptake and lists the advantages and disadvantages of each assay. Among these assays is the new non-radioactive Glucose ...

In steady-state 3T3-L1 adipocytes, AQP7 is localized at the periphery of the nucleus. When lipolysis is required, epinephrine production increases and elevates intracellular levels of cyclic AMP ...

A group of researchers led by Kazuya Kikuchi, professor at the Graduate School of Engineering, Osaka University, clarified the role of a N-glycan chain on glucose transporter type 4 (GLUT4) by ...