Uni Medical care on Instagram: "Frostbite is a form of gangrene caused by freezing of the skin and deeper tissues. It involves both direct injury from ice crystal formation and indirect injury from impaired microcirculation, leading to severe tissue damage. 🟥🟥 Cold exposure can destroy tissue directly through intracellular ice crystals or indirectly by interstitial freezing that extracts water from the cells. At the same time, circulation to the frozen area undergoes profound changes. 🟥🟥 The